Factor II is a protein made in the liver & plays an important role in blood clotting along with other factors. Deficiency of Factor II is rare and varies from mild to severe. It can be inherited or can be acquired due to medications or autoimmune disease. Hereditary deficiency is rare and both parents must carry the defective gene to pass it on to their child. Symptoms include unexplained bruising, prolonged nose bleed, bleeding from gums, heavy periods, delayed clotting following surgery or injury.