Immunoglobulins are proteins produced by plasma cells, a type of white blood cells and are an important part of your defense system. There are 5 types of immunoglobulins namely IgG, IgM, IgA, IgE & IgD. Immunoglobulin G is an important component of your defense system & constitutes 80% of the total immunoglobulins in your body. It is divided into 4 subclasses namely IgG1, IgG2, IgG3 & IgG4 of which 65% is IgG1. IgG4 comprises 4% of the total IgG in your body. This is a useful test when you have symptoms of immunodeficiency but your total IgG levels are normal.