Creatinine is a chemical compound left over from energy producing processes in your muscles. Healthy kidneys filter creatinine out of the blood & it exits your body as a waste product in urine. Your doctor prescribes this test if you have signs or symptoms of kidney disease and to screen for kidney disease if you have diabetes, high blood pressure or other conditions that increase the risk of kidney damage. In this test, creatinine is measured in blood as well as in 24 hour collection of urine. Accurate collection of the urine sample is important.